Master Yin Shun’s philosophy in “The Sentient World” emphasizes the existence of sentient beings as a combination of body and mind, often troubled by aging, illness, and death. These are considered the “eight sufferings” in Buddhism, highlighting the suffering of life’s impermanence. If one can confront these, they can find methods for liberation and the ability to transcend. This article first explores the connection between the concepts of “no-self theory” and “dependent origination of emptiness” with palliative care literature. It then analyzes cases to illustrate the application of Master Yin Shun’s life perspective in practical palliative care. Finally, it is found that Master Yin Shun’s life perspective aligns with the needs of patients in the later stages of illness and their families, providing a basis for modern palliative care practice. It suggests broader practical applications to offer more support and guidance to those facing life’s challenges.