By means of the natural history of "zero", and with "zero" as a theme to broach, we can think metaphysical questions in double senses: The one kind is the epistemological metaphysics, based on the perceptual-rational-differentiate; it is related with the Zero as vacancy between numbers. Another kind is genetic metaphysics, based on the source-evolution-differentiate, it is related with the zero between negative and positive number. In this respect the zero represents a domain of metaphysic: We may infinitely approach it, but never achieve actually. The zero is polymerization-spot of all relations, also the starting-point of all relations, but it self does not have any determinable content. This is the essence of zero, also the essence of all metaphysic.