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| Plasma Homocysteine Levels in Taiwanese Vegetarians Are Higher than Those of Omnivores | ||
| 作者 | Hung, Chien-jung ; Huang, Po-Chao ; Lu, Shao-Chun ; Li, Yi-Hwei ; Huang, Hsien-Bin ; Lin, Bi-Fong |
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| 出處題名 | The Journal of Nutrition |
| 卷期 | v.132 n.2 |
| 出版日期 | 2002.02.01 |
| 頁次 | 152 - 158 |
| 出版者 | The American Institute of Nutrition |
| 出版地 | US [美國] |
| 資料類型 | 期刊論文=Journal Article |
| 使用語言 | 英文=English |
| 關鍵詞 | homocysteine; vegetarian diet; vitamin B-12; vegetarianism; folate; humans |
| 摘要 | Mild hyperhomocysteinemia is an independent risk factor for cardiovascular disease and may result from a deficiency of folate，vitamin B-6 or vitamin B-12. Because vitamin B-12 deficiency is often associated with vegetarianism，this study was designed to examine the effect of Taiwanese vegetarian diets on B-vitamin status and plasma homocysteine levels. Female Buddhist lacto-vegetarians (n = 45; 31-45y) and matched omnivores (n = 45) recruited in Hualien，Taiwan，were investigated. Taiwanese vegetarians consumed normal amount of folate，but only 21% of Taiwan Recommended Daily Nutrient Allowances (RDNA) values of vitamin B-12. Compared with the omnivores, the vegetarians had significantly higher levels of plasma folate (14.79 +/- 7.70 vs.11.98 +/- 8.29 nmol/L)，but lower levels of vitamin B-12 (207.7 +/- 127.1 vs. 403.5 +/- 138.9 pmol/L). Fasting plasma homocysteine levels were significantly higher in vegetarians than in omnivores (mean：11.20 +/- 4.27 vs. 8.64 +/- 2.06 micromol/L; median：10.5 vs. 8.5 micromol/L). Fasting plasma homocysteine was inversely correlated with plasma folate and vitamin B-12 in the vegetarian group. Multiple regression analysis revealed that plasma folate，vitamin B-12 and creatinine were independent determinants of homocysteine variation and contributed to 38.6% of homocysteine variation in the vegetarians. Compared with the omnivores, vegetarians also had significantly lower serum levels of valine，isoleucine，leucine，lysine，alanine and arginine，but higher levels of glycine. In the vegetarian group，fasting plasma homocysteine correlated negatively with serum threonine，lysine，histidine，arginine and cystine，and these amino acids contributed to 38.7% of homocysteine variation. In conclusion，the Buddhist nuns who consumed a lacto-vegetarian diet had mildly elevated fasting plasma homocysteine levels presumably due to lower levels of plasma vitamin B-12. |
| 目次 | SUBJECTS AND METHODS 153 Subjects Dietary assessment Anthropometric measurements and blood collection Laboratory measurements Statistical analysis RESULTS 153 DISCUSSION 155 Acknowledgments 157 LITERATURE CITED 157 |
| ISSN | 00223166 |
| 點閱次數 | 291 |
| 建檔日期 | 2003.09.19 |
| 更新日期 | 2016.11.25 |
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